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1994-08-09
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Document 0001
DOCN M9480001
TI Immunohistochemical characterization of inflammatory cells and
immunologic activation markers in muscle and nerve biopsy specimens from
patients with systemic polyarteritis nodosa.
DT 9410
AU Cid MC; Grau JM; Casademont J; Campo E; Coll-Vinent B; Lopez-Soto A;
Ingelmo M; Urbano-Marquez A; Hospital Clinic i Provincial, University of
Barcelona, Spain.
SO Arthritis Rheum. 1994 Jul;37(7):1055-61. Unique Identifier : AIDSLINE
MED/94296454
AB OBJECTIVE. To investigate the phenotype of infiltrating cells in classic
lesions of polyarteritis nodosa (PAN). METHODS. Twenty-one muscle and 10
sural nerve biopsy samples from 24 patients with systemic PAN were
studied using avidin-biotin-peroxidase and alkaline
phosphatase-anti-alkaline phosphatase immunohistochemical techniques.
RESULTS. The inflammatory infiltrates consisted mainly of macrophages
(41%) and T lymphocytes (41%), particularly of the CD4+ subset.
Granulocytes were present in varying quantities (0-45%) and were more
abundant in heavily infiltrated vessels and in those with fibrinoid
necrosis. Dendritic cells could be identified in 4 samples.
Proliferating and interleukin-2 receptor-expressing cells, present in
71% and 79% of the patients, respectively, were more frequent in
untreated patients. CONCLUSION. T cell-mediated immune mechanisms may
play a role in the development and perpetuation of PAN lesions.
DE Adult Aged Biopsy CD4-CD8 Ratio Female
Granulocytes/CHEMISTRY/IMMUNOLOGY/PATHOLOGY Histocompatibility Antigens
Class II/ANALYSIS Human Immunohistochemistry
Macrophages/CHEMISTRY/IMMUNOLOGY/PATHOLOGY Male Middle Age
Muscles/*PATHOLOGY Nerve Tissue/*PATHOLOGY Periarteritis
Nodosa/*ETIOLOGY/IMMUNOLOGY/*PATHOLOGY Phenotype Receptors,
Interleukin-2/ANALYSIS Support, Non-U.S. Gov't
T-Lymphocytes/CHEMISTRY/IMMUNOLOGY/PATHOLOGY T4
Lymphocytes/CHEMISTRY/IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).